Organolithium Reactions
Characteristics of Organolithium Reactions
1. Fast reaction rate;
2. Large heat release;
3. Low-temperature reaction (-78℃);
4. Anhydrous and oxygen-free environment required;
5. Complex and uncontrollable side reactions;
6. Easy deterioration of raw materials.
Technical Improvement of Continuous Process (Liquid-phase Reaction)
1）Equipment selection: Microchannel reactor or micromixer + residence time reactor；
2）Common issues: Presence of moisture leading to equipment blockage;
3）Common measures: Temperature elevation to increase rate (-40~-20℃), multi-site feeding,
two-step series connection, staged temperature control, dehydration treatment, and N₂ protection.
| Reactor Type | Feeding Method | Reaction Temperature /℃ | Reaction Time | Conversion /% | Yield /% |
|---|---|---|---|---|---|
| Flask Reactor | Stepwise Dropwise Addition | -80~-70 | 5 h | 99.5% | 80~85 |
| Microreactor | Three-step Sequential Feeding | -30 | 1 min | 99.9% | 86 |
